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Visibly younger skin — in 12 weeks.

No 12-step routine · No irritation spiral · No derm visit
Skin Protocol — AM, PM, SPF bottles + packaging
Available now · 3 components

Skin Protocol.

Visible improvements in 6–12 weeks

The Rx skincare protocol Hims can't prescribe. A compounded night treatment, a peptide support serum, and daily photoprotection — engineered to work as one system. This is where your longevity stack begins.

Full Skin Protocol
$99/month
PM + AM + SPF · ~60-day supply
Solo options
From $21/mo
Build piece by piece
Prescribed by US-licensed clinicians
Compounded at a 503A licensed pharmacy
$0 if your clinician doesn't approve
Build your Skin Protocol

Three steps.
One system.

Treatment · Rx

PM Protocol

Tretinoin · Azelaic · Niacinamide · GHK-Cu

Compounded Rx night treatment. The workhorse — drives visible aging reversal.

Learn more →
Support · OTC

AM Protocol

Matrixyl 3000 · Argireline · GHK-Cu

Peptide serum. Supports collagen, softens PM Protocol irritation.

Learn more →
Protection · OTC

SPF Protocol

SPF 50 · PA++++ · Broad Spectrum

Essential with PM Protocol. Tretinoin makes skin sun-sensitive — SPF protects what the Rx layer builds.

Learn more →
Your Skin Protocol
3 of 3 active
PM · AM · SPF
Total
$99/mo
Activate protocol
Clinical formulations
Rx-grade, research-backed
Systemic approach
Treatment + support + protection
Daily rituals
One step. Built to stick.
Visible results
Measured at 12 weeks
Projected outcome

Drag to see 12 weeks on protocol.

Based on median clinical response. Individual results vary.

Before protocol After 12 weeks on protocol
Before · Week 0
Week 12
Week 0Week 12
Questions

Answered.

Can I order just one component?+

Yes — each is available solo. But the three compound: PM drives change, AM keeps it tolerable, SPF preserves the outcome. Removing any one reduces the others' effectiveness.

Do I need all three to start?+

PM + SPF is the non-negotiable baseline. Tretinoin without daily SPF accelerates damage instead of reversing it. AM is strongly recommended but can be added later.

How long until I see results?+

Most users see smoother texture and tone within 8–12 weeks. Meaningful change in fine lines and photoaging compounds over 6–12 months of consistent use.

What if my skin reacts badly?+

Message your clinician. Strength can be adjusted — your clinician can step tretinoin down to a gentler dose within 24 hours. We don't let irritation cause you to quit.

The strength gap

Why drugstore skincare
cannot do this.

It's not branding. It's the law. The actives that actually reverse aging require a prescription — and that's exactly what's inside Skin Protocol.

Drugstore skincare
"Anti-aging"
  • Retinol capped at 0.025% (cosmetic-grade)
  • Cannot legally claim to reverse aging
  • "Peptides" that degrade in jars within weeks
  • 10+ separate products to layer
  • No clinician oversight
  • Marginal results, marketed as miracles
Pharmacy-grade
Skin Protocol
Real Rx
  • Tretinoin 0.025% — 10× stronger than retinol
  • Clinically proven to reverse photoaging
  • Pharmaceutical-grade actives, fresh-compounded
  • Four actives in one nightly bottle
  • US-licensed clinician reviews + adjusts
  • Built to actually work — and to actually use
Activate protocol

Pharmaceutical compound · 503A pharmacy · Clinician-prescribed

The math

Same Rx.
1/3 the cost.

Dermatologist
$300+ / visit
  • 6–12 week wait for appointment
  • One 15-minute consult
  • Rx handed off to pharmacy
  • You figure out routine alone
  • $180/mo for 3 separate products
Drugstore / DIY
$60–140 / mo
  • No prescription compounds
  • Retinol ≈ 20× weaker than Rx tretinoin
  • No clinical oversight
  • 10+ products to manage
  • Marginal results at best
Smarter path
Protocolo
$99 / mo
  • Approved in 24–48 hrs online
  • US-licensed clinician, full review
  • Compound shipped from US pharmacy
  • AM/PM protocol, built to execute
  • Message your clinician anytime
Activate protocol

Toggle on the foundation.
Start your intake.

Two minutes. Clinician reviews in 24 hours. You pay nothing until approved.

SPF Protocol in hand
Built for daily use

Designed to live
on your shelf.

Not in a drawer. Not at the back of the cabinet. Three minimal bottles you actually want to look at — engineered to survive humidity, travel, and the morning rush.

Recyclable mono-material packaging
TSA-friendly travel sizes · 30-50ml
Air-tight pump bottles · stable formulas, no contamination
Peer-reviewed evidence

The clinical data.

We read the studies so you don't have to. Here's the evidence behind Skin Protocol.

1.Landmark 24-week double-blind trial establishing tretinoin 0.05% as the gold standard for photoaging reversal.
J Am Acad Dermatol, 1988 →
2.5% niacinamide reduces wrinkles, hyperpigmentation, and improves skin elasticity in 50 subjects over 12 weeks.
Dermatol Surg, 2005 →
3.Review of GHK-Cu peptide mechanisms: stimulates collagen, elastin, and tissue repair at micromolar concentrations.
Biomed Res Int, 2015 →
4.Azelaic acid 15% shown superior to tretinoin in treating postinflammatory hyperpigmentation in men.
Cutis, 2011 →
5.Topical tretinoin + niacinamide combination: synergistic improvement in tone and texture vs. either alone.
J Cosmet Dermatol, 2019 →
6.Daily SPF 50+ reduces photoaging markers by 24% over 4.5 years in a randomized controlled trial.
Ann Intern Med, 2013 →

Selected peer-reviewed references. Full bibliography available in your patient portal.

Skin Protocol
$99/mo
Activate protocol
@protocolo

The protocol,
in the wild.

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Protocolo in the wild